2026
Preprint
Spatially patterned, spectral single-molecule microscopy
Beckwith, J. S.†,*; Cullinane, B.†; Heraghty, D. F.; Krokowski, S.; Jones, C. L.; Yang, S.; Gregory, R. C.; Zhang, Y.; Floto, R. A.; Santos, A. M.; Davis, S. J.; Vendruscolo, M.; Klenerman, D.; Lindo, V.; Sankaran, P. K.; Lee, S. F.*
bioRxiv, 2026, 2026.04.08.715690
2026
Volumetric single-molecule tracking inside subcellular structures
Daly, S.; Chambers, J. E.; Jones, C.; Fu, B.; Manton, J. D.; Beckwith, J. S.; Marciniak, S. J.; Gershlick, D. C.; Lee, S. F.
Small, 2026, 22 (9)
2025
Preprint
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
Cotton, M. W.; Venkatesan, S.; Beckwith, J. S.; Böken, D.; Xu, C. K.; Breiter, J. C.; Berkowicz, L. E.; Salazar, L. S.; Schulze, A. V.; Andrzejewska, E. A.; Brock, E. E.; Han, H. L.; Schneider, M. M.; Sahtoe, D. D.; Baker, D.; Rowe, J. B.; Goriely, A.; McEwan, W. A.; Knowles, T. P. J.; Lee, S. F.; Halfmann, R.; Klenerman, D.; Meisl, G.
bioRxiv, 2025, 2025.09.08.674880
2025
Preprint
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R.†; Grant-Peters, M.†; Beckwith, J. S.†; Toomey, C. E.; Popovic, R.; Breiter, J. C.; Brenton, J. W.; Fairbrother-Browne, A.; Strohbuecker, S.; Lachica, J.; Rodriguez-Lopez, M.; Brock, E. E.; Fu, B.; Nahidiazar, L.; Lopez-Garcia, P.; Ferguson, R.; Saleeb, R. S.; Lucas-Clarke, H.; Penverne, A.; D'Sa, K.; Pang, C. W.; Horrocks, M. H.; Vendruscolo, M.; Wood, N.; Lee, S. F.; Ryten, M.; Gandhi, S.
bioRxiv, 2025, 2025.08.25.671921
2025
Preprint
α-Synuclein driven cell susceptibility in Parkinson's disease
Breiter, J. C.†; Beckwith, J. S.†; Brock, E. E.; Lachica, J.; Toomey, C. E.; Fu, B.; Ryten, M.; Weiss, L. E.; Wood, N. W.; Gandhi, S.; Vendruscolo, M.; Lee, S. F.
bioRxiv, 2025, 2025.08.19.670819
2025
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue
Andrews, R.; Fu, B.; Toomey, C. E.; Breiter, J. C.; Lachica, J.; Beckwith, J. S.; Tian, R.; Brock, E. E.; Needham, L.-M.; Chant, G. J.; Loiseau, C.; Deconfin, A.; Baspin, K.; Popovic, R.; Evans, J.; Goh, Y.; Kurt, B.; Senicar, L.; Edmonds, M.; Bartels, T.; Bengoa-Vergniory, N.; Magill, P. J.; Jaunmuktane, Z.; Freeman, O. J.; Taylor, B. J. M.; Hardy, J.; Lashley, T.; Ryten, M.; Vendruscolo, M.; Wood, N. W.; Weiss, L. E.; Gandhi, S.; Lee, S. F.
Nat. Biomed. Eng., 2025, 1–13
2024
RASP: Optimal single puncta detection in complex cellular backgrounds
Fu, B.; Brock, E. E.; Andrews, R.; Breiter, J. C.; Tian, R.; Toomey, C. E.; Lachica, J.; Lashley, T.; Ryten, M.; Wood, N. W.; Vendruscolo, M.; Gandhi, S.; Weiss, L. E.; Beckwith, J. S.*; Lee, S. F.*
J. Phys. Chem. B, 2024, 128 (15), 3585–3597
2024
High-density volumetric super-resolution microscopy
Daly, S.; Fernandes, J. F.; Bruggeman, E.; Handa, A.; Peters, R.; Benaissa, S.; Zhang, B.; Beckwith, J. S.; Sanders, E. W.; Sims, R. R.; Klenerman, D.; Davis, S. J.; O'Holleran, K.; Lee, S. F.
Nat. Commun., 2024, 15 (1), 1940
2022
Parabolic potential surfaces localize charge carriers in nonblinking long-lifetime "giant" colloidal quantum dots
Pálmai, M.; Beckwith, J. S.; Emerson, N. T.; Zhao, T.; Kim, E. B.; Yin, S.; Parajuli, P.; Tomczak, K.; Wang, K.; Sapkota, B.; Tien, M.; Jiang, N.; Klie, R.; Yang, H.; Snee, P. T.
Nano Lett., 2022, 22 (23), 9470–9476
2022
Chemistry of Materials 2024 Lectureship & Best Paper Award
Beyond the threshold: a study of chalcogenophene-based two-photon initiators
Lunzer, M.†; Beckwith, J. S.†; Chalupa-Gantner, F.; Rosspeintner, A.; Licari, G.; Steiger, W.; Hametner, C.; Liska, R.; Fröhlich, J.; Vauthey, E.; Ovsianikov, A.; Holzer, B.
Chem. Mater., 2022, 34 (7), 3042–3052
2022
2021
2021
Editors' Choice Article 2021
Leveraging lifetime information to perform real-time 3D single-particle tracking in noisy environments
Zhao, T.; Beckwith, J. S.; Amin, M. J.; Pálmai, M.; Snee, P. T.; Tien, M.; Yang, H.
J. Chem. Phys., 2021, 155 (16), 164201
2021
2021
2021
Two RuII linkage isomers with distinctly different charge transfer photophysics
Tisaun, J.; Laramée-Milette, B.; Beckwith, J. S.; Bierwagen, J.; Hanan, G. S.; Reber, C.; Hauser, A.; Moucheron, C.
Inorg. Chem., 2021, 60 (6), 3677–3689
2020
2019
2018
Machine learning for analysis of time-resolved luminescence data
Đorđević, N.; Beckwith, J. S.; Yarema, M.; Yarema, O.; Rosspeintner, A.; Yazdani, N.; Leuthold, J.; Vauthey, E.; Wood, V.
ACS Photonics, 2018, 5 (12), 4888–4895
2018
2018
Influence of the hydrogen-bond interactions on the excited-state dynamics of a push–pull azobenzene dye: the case of Methyl Orange
Nançoz, C.; Licari, G.; Beckwith, J. S.; Soederberg, M.; Dereka, B.; Rosspeintner, A.; Yushchenko, O.; Letrun, R.; Richert, S.; Lang, B.; Vauthey, E.
Phys. Chem. Chem. Phys., 2018, 20 (10), 7254–7264
2018
Energy transfer and charge separation dynamics in photoexcited pyrene–bodipy molecular dyads
Fakis, M.; Beckwith, J. S.; Seintis, K.; Martinou, E.; Nançoz, C.; Karakostas, N.; Petsalakis, I.; Pistolis, G.; Vauthey, E.
Phys. Chem. Chem. Phys., 2018, 20 (2), 837–849
2017
Specific monitoring of excited-state symmetry breaking by femtosecond broadband fluorescence upconversion spectroscopy
Beckwith, J. S.; Rosspeintner, A.; Licari, G.; Lunzer, M.; Holzer, B.; Fröhlich, J.; Vauthey, E.
J. Phys. Chem. Lett., 2017, 8 (23), 5878–5883
2016
Single-molecule imaging of individual amyloid protein aggregates in human biofluids
Horrocks, M. H.; Lee, S. F.; Gandhi, S.; Magdalinou, N. K.; Chen, S. W.; Devine, M. J.; Tosatto, L.; Kjaergaard, M.; Beckwith, J. S.; Zetterberg, H.; Iljina, M.; Cremades, N.; Dobson, C. M.; Wood, N. W.; Klenerman, D.
ACS Chem. Neurosci., 2016, 7 (3), 399–406